Parathyroid hormone-related protein secretion is inhibited by oestradiol and stimulated by antioestrogens in KPL-3C human breast cancer cells
نویسندگان
چکیده
منابع مشابه
Parathyroid hormone related protein and hypercalcaemia in breast cancer.
OBJECTIVE To see whether parathyroid hormone related protein has a humoral role in breast cancer. DESIGN Plasma concentrations and tumour expression of parathyroid hormone related protein were determined (by two site immunoradiometric assay and immunohistochemistry respectively) in women with breast cancer and related to the presence of bone metastases and serum calcium concentrations. SUBJ...
متن کاملExpression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells.
Thymic epithelial cells are an important source of cytokines and other regulatory peptides which guide thymocyte proliferation and maturation. Parathyroid hormone-related protein (PTHrP), a cytokine-like peptide, has been reported to affect the proliferation of lymphocytes in vitro. The studies presented here were undertaken to test the hypotheses that PTHrP is produced locally within the thymu...
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متن کاملImmunohistochemical localization of parathyroid hormone-related protein in human breast cancer.
Parathyroid hormone-related protein (PTHrP) is known to be a causative factor in humoral hypercalcemia of malignancy. A polyclonal rabbit antiserum directed against the amino-terminal region of the protein and immunoperoxidase methods have been used to locate the presence of PTHrP in a series of 102 consecutive invasive breast tumors removed surgically from normocalcemic women. Positive PTHrP s...
متن کاملHigh phosphate level directly stimulates parathyroid hormone secretion and synthesis by human parathyroid tissue in vitro.
Phosphate retention plays an important role in the pathogenesis of secondary hyperparathyroidism in patients with renal failure. In in vitro studies, high extracellular phosphate levels directly stimulate PTH secretion in rat and bovine parathyroid tissue. The present study evaluates the effect of high phosphate levels on the secretion of PTH and the production of prepro PTH mRNA in human hyper...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1997
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1997.310